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1

Synthesis of HPMA Copolymers Containing Doxorubicin Bound via a Hydrazone Linkage. Effect of Spacer on Drug Release and in vitro Cytotoxicity

Tomáš Etrych, Petr Chytil, Markéta Jelínková, Blanka Říhová, Karel Ulbrich

Journal:

Macromolecular Bioscience

Year:

2002

Language:

english

File:

PDF, 266 KB

english, 2002

2

Cytotoxicity and immunostimulation: double attack on cancer cells with polymeric therapeutics

Blanka Říhová, Lubomír Kovář, Marek Kovář, Ondřej Hovorka

Journal:

Trends in Biotechnology

Year:

2009

Language:

english

File:

PDF, 628 KB

english, 2009

3

Lectin-HPMA copolymer conjugates: potential oral drug carriers for targeting diseased tissues

Susan Wróblewski, Pavla Kopečková, Blanka Říhová, Jindřich Kopeček

Journal:

Macromolecular Chemistry and Physics

Year:

1998

Language:

english

File:

PDF, 2.00 MB

english, 1998

4

N-(2-hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin. I. New synthesis, physicochemical characterization and preliminary biological evaluation

Tomáš Etrych, Tomáš Mrkvan, Petr Chytil, Čestmír Koňák, Blanka Říhová, Karel Ulbrich

Journal:

Journal of Applied Polymer Science

Year:

2008

Language:

english

File:

PDF, 162 KB

english, 2008

5

Antitumor activity of IL-2/anti-IL-2 mAb immunocomplexes exerts synergism with that of N-(2-hydroxypropyl)methacrylamide copolymer-bound doxorubicin conjugate due to its low immunosuppressive activity

Jakub Tomala, Helena Chmelova, Jiri Strohalm, Karel Ulbrich, Milada Sirova, Blanka Rihova, Marek Kovar

Journal:

International Journal of Cancer

Year:

2011

Language:

english

File:

PDF, 1.28 MB

english, 2011

6

Conjugates of Antibody-Targeted PEG Multiblock Polymers with Doxorubicin in Cancer Therapy

Michal Pechar, Karel Ulbrich, Markéta Jelínková, Blanka Říhová

Journal:

Macromolecular Bioscience

Year:

2003

Language:

english

File:

PDF, 213 KB

english, 2003

7

Thermoresponsive, Hydrolytically Degradable Polymer Micelles Intended for Radionuclide Delivery

Martin Hruby, Cestmir Konak, Jan Kucka, Miroslav Vetrik, Sergey K. Filippov, David Vetvicka, Hana Mackova, Goran Karlsson, Katarina Edwards, Blanka Rihova, Karel Ulbrich

Journal:

Macromolecular Bioscience

Year:

2009

Language:

english

File:

PDF, 384 KB

english, 2009

8

The effects of 5-fluorouracil on immunocompetent cells depend on the genotype of experimental animals used

Blanka Rihova, V. Vetvicka, P.W. Kincade

Journal:

Immunopharmacology

Year:

1988

Language:

english

File:

PDF, 543 KB

english, 1988

9

Implantation of ultrathin, biofunctionalized polyimide membranes into the subretinal space of rats

Sylvie Julien, Tobias Peters, Focke Ziemssen, Blanca Arango-Gonzalez, Susanne Beck, Hagen Thielecke, Heiko Büth, Sandra Van Vlierberghe, Milada Sirova, Pavel Rossmann, Blanka Rihova, Etienne Schacht,

Journal:

Year:

2011

Language:

english

File:

PDF, 2.34 MB

english, 2011

10

Biocompatibility and immunocompatibility of water-soluble polymers based on HPMA

Blanka Říhová

Journal:

Composites Part B: Engineering

Year:

2007

Language:

english

File:

PDF, 233 KB

english, 2007

11

N-(2-hydroxypropyl) methacrylamide copolymers containing pendant saccharide moieties: Synthesis and bioadhesive properties

Ramesh C. Rathi, Pavla Kopečková, Blanka Říhová, Jindŕich Kopeček

Journal:

Journal of Polymer Science Part A: Polymer Chemistry

Year:

1991

Language:

english

File:

PDF, 621 KB

english, 1991

12

Treatment with HPMA copolymer-based doxorubicin conjugate containing human immunoglobulin induces long-lasting systemic anti-tumour immunity in mice

Milada Sirova, Jiri Strohalm, Vladimir Subr, Daniela Plocova, Pavel Rossmann, Tomas Mrkvan, Karel Ulbrich, Blanka Rihova

Journal:

Cancer Immunology, Immunotherapy

Year:

2007

Language:

english

File:

PDF, 666 KB

english, 2007

13

Salivary gland extract fromIxodes ricinustick modulates the host immune response towards the Th2 cytokine profile

Lubomír Kovář, Jan Kopecký, Blanka Říhová

Journal:

Parasitology Research

Year:

2002

Language:

english

File:

PDF, 250 KB

english, 2002

14

Preclinical Evaluation of Linear HPMA-Doxorubicin Conjugates with pH-Sensitive Drug Release: Efficacy, Safety, and Immunomodulating Activity in Murine Model

Milada Sirova, Tomas Mrkvan, Tomas Etrych, Petr Chytil, Pavel Rossmann, Marketa Ibrahimova, Lubomir Kovar, Karel Ulbrich, Blanka Rihova

Journal:

Pharmaceutical Research

Year:

2010

Language:

english

File:

PDF, 437 KB

english, 2010

15

Doxorubicin attached to HPMA copolymer via amide bond modifies the glycosylation pattern of EL4 cells

Lubomir Kovar, Tomas Etrych, Martina Kabesova, Vladimir Subr, David Vetvicka, Ondrej Hovorka, Jiri Strohalm, Jan Sklenar, Petr Chytil, Karel Ulbrich, Blanka Rihova

Journal:

Year:

2010

Language:

english

File:

PDF, 430 KB

english, 2010

16

HPMA-based Biodegradable Hydrogels Containing Different Forms of Doxorubicin Antitumor Effects and Biocompatibility

BLANKA ŘÍHOVÁ, JAN ŠROGL, MARKÉTA JELÍNKOVÁ, O. HOVORKA, MAGDA BUREŠOVÁ, VLADIMÍR ŠUBR, KAREL ULBRICH

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 787 KB

english, 1997

17

Synthesis of Biodegradable Polymers for Controlled Drug Release

KAREL ULBRICH, MICHAL PECHAR, JIŘÍ STROHALM, VLADIMÍR ŠUBR, BLANKA ŘÍHOVÁ

Journal:

Annals of the New York Academy of Sciences

Year:

1997

Language:

english

File:

PDF, 492 KB

english, 1997

18

Targetable photoactivalable drugs. 3. In vitro efficacy of polymer bound chlorin e6 toward human hepatocarcinoma cell line (PLC/PRF/5) targeted with galactosamine and to mouse splenocytes targeted with anti-Thy 1.2 antibodies

Blanka Říhová, Nancy L. Krinick, Jindřich Kopeček

Journal:

Journal of Controlled Release

Year:

1993

Language:

english

File:

PDF, 1.57 MB

english, 1993

19

Synthesis and evaluation of macromolecular prodrugs of mitomycin C

Anne De Marre, Heidi Soyez, Etienne Schacht, Mahmood A. Shoaibi, Leonard W. Seymour, Blanka Rihova

Journal:

Journal of Controlled Release

Year:

1995

Language:

english

File:

PDF, 787 KB

english, 1995

20

Comparison of the binding kinetics of antibody-targeted N-(2-hydroxypropyl) methacrylamide (HPMA)-bound doxorubicin in vitro and in vivo

Marek Št'astný, Blanka Říhová, Jiří Strohalm, Karel Ulbrich

Journal:

Journal of Controlled Release

Year:

1996

Language:

english

File:

PDF, 583 KB

english, 1996

21

In vitro bioadhesion of carbohydrate-containing N-(2-hydroxypropyl) methacrylamide copolymers to the GI tract of guinea pigs

Blanka Říhová, Ramesh C. Rathi, Pavla Kopečková, Jindřich Kopeček

Journal:

International Journal of Pharmaceutics

Year:

1992

Language:

english

File:

PDF, 861 KB

english, 1992

22

Clinical experience with anthracycline antibiotics–HPMA copolymer–human immunoglobulin conjugates

Journal:

Advanced Drug Delivery Reviews

Year:

2009

Language:

english

File:

PDF, 325 KB

english, 2009

23

Chemotherapy based on HPMA copolymer conjugates with pH-controlled release of doxorubicin triggers anti-tumor immunity

Tomas Mrkvan, Milada Sirova, Tomas Etrych, Petr Chytil, Jiri Strohalm, Dana Plocova, Karel Ulbrich, Blanka Rihova

Journal:

Journal of Controlled Release

Year:

2005

Language:

english

File:

PDF, 154 KB

english, 2005

24

Properties of HPMA copolymer–doxorubicin conjugates with pH-controlled activation: Effect of polymer chain modification

Petr Chytil, Tomáš Etrych, Čestmír Koňák, Milada Šírová, Tomáš Mrkvan, Blanka Říhová, Karel Ulbrich

Journal:

Journal of Controlled Release

Year:

2006

Language:

english

File:

PDF, 263 KB

english, 2006

25

Star-shaped immunoglobulin-containing HPMA-based conjugates with doxorubicin for cancer therapy

Tomáš Etrych, Tomáš Mrkvan, Blanka Říhová, Karel Ulbrich

Journal:

Journal of Controlled Release

Year:

2007

Language:

english

File:

PDF, 381 KB

english, 2007

26

Conjugates of doxorubicin with graft HPMA copolymers for passive tumor targeting

Tomáš Etrych, Petr Chytil, Tomáš Mrkvan, Milada Šírová, Blanka Říhová, Karel Ulbrich

Journal:

Journal of Controlled Release

Year:

2008

Language:

english

File:

PDF, 498 KB

english, 2008

27

HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity

Tomáš Etrych, Jiří Strohalm, Lubomír Kovář, Martina Kabešová, Blanka Říhová, Karel Ulbrich

Journal:

Journal of Controlled Release

Year:

2009

Language:

english

File:

PDF, 598 KB

english, 2009

28

Biodegradable star HPMA polymer–drug conjugates: Biodegradability, distribution and anti-tumor efficacy

Tomáš Etrych, Lubomír Kovář, Jiří Strohalm, Petr Chytil, Blanka Říhová, Karel Ulbrich

Journal:

Journal of Controlled Release

Year:

2011

Language:

english

File:

PDF, 822 KB

english, 2011

29

Biological evaluation of mitomycin C bound to a biodegradable polymeric carrier

Heidi Soyez, Etienne Schacht, Marketa Jelinkova, Blanka Rihova

Journal:

Journal of Controlled Release

Year:

1997

Language:

english

File:

PDF, 1.05 MB

english, 1997

30

Biocompatibility of biomaterials: hemocompatibility, immunocompatiblity and biocompatibility of solid polymeric materials and soluble targetable polymeric carriers

Blanka Říhová

Journal:

Advanced Drug Delivery Reviews

Year:

1996

Language:

english

File:

PDF, 2.19 MB

english, 1996

31

Regulatory T cells and their prognostic value for patients with squamous cell carcinoma of the head and neck

Jan Boucek, Tomas Mrkvan, Martin Chovanec, Martin Kuchar, Jaroslav Betka, Vladimir Boucek, Marie Hladikova, Jan Betka, Tomas Eckschlager, Blanka Rihova

Journal:

Journal of Cellular and Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 681 KB

english, 2010

32

Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system

Jäger, Eliézer, Jäger, Alessandro, Etrych, Tomáš, Giacomelli, Fernando Carlos, Chytil, Petr, Jigounov, Alexander, Putaux, Jean-Luc, Říhová, Blanka, Ulbrich, Karel, Štěpánek, Petr

Journal:

Year:

2012

Language:

english

File:

PDF, 655 KB

english, 2012

33

Dimerization of an Immunoactivating Peptide Derived from Mycobacterial hsp65 Using N -Hydroxysuccinimide Based Bifunctional Reagents Is Critical for Its Antitumor Properties

Bezouška, Karel, Kubínková, Zuzana, Stříbný, Jiří, Volfová, Barbora, Pompach, Petr, Kuzma, Marek, Šírová, Milada, Říhová, Blanka

Journal:

Bioconjugate Chemistry

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

34

Spectral analysis of doxorubicin accumulation and the indirect quantification of its DNA intercalation

Ondřej Hovorka, Vladimír Šubr, David Větvička, Lubomír Kovář, Jiří Strohalm, Martin Strohalm, Aleš Benda, Martin Hof, Karel Ulbrich, Blanka Říhová

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2010

Language:

english

File:

PDF, 2.27 MB

english, 2010

35

Immunogenicity and immunomodulatory properties of HPMA-based polymers

Blanka Říhová, Marek Kovář

Journal:

Advanced Drug Delivery Reviews

Year:

2010

Language:

english

File:

PDF, 292 KB

english, 2010

36

Polymer Carriers for Anticancer Drugs Targeted to EGF Receptor

Studenovsky, Martin, Pola, Robert, Pechar, Michal, Etrych, Tomas, Ulbrich, Karel, Kovar, Lubomir, Kabesova, Martina, Rihova, Blanka

Journal:

Macromolecular Bioscience

Year:

2012

Language:

english

File:

PDF, 312 KB

english, 2012

37

Detection of mouse cells producing antibodies against the azophenylarsonic group by haemolytic plaque assay

Blanka Říhová, Helena Tlaskalová, Ivan Řiha

Journal:

Journal of Immunological Methods

Year:

1980

Language:

english

File:

PDF, 328 KB

english, 1980

38

Biological properties of targetable poly[N-(2-hydroxypropyl)-methacrylamide]-antibody conjugates

Blanka Řihová, Jindřich Kopeček

Journal:

Journal of Controlled Release

Year:

1985

Language:

english

File:

PDF, 1.75 MB

english, 1985

39

HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity

Etrych, Tomáš, Šubr, Vladimír, Strohalm, Jiří, Šírová, Milada, Říhová, Blanka, Ulbrich, Karel

Journal:

Journal of Controlled Release

Year:

2012

Language:

english

File:

PDF, 793 KB

english, 2012

40

Combination chemotherapy using core-shell nanoparticles through the self-assembly of HPMA-based copolymers and degradable polyester

Jäger, Eliézer, Jäger, Alessandro, Chytil, Petr, Etrych, Tomáš, Říhová, Blanka, Giacomelli, Fernando Carlos, Štěpánek, Petr, Ulbrich, Karel

Journal:

Journal of Controlled Release

Year:

2013

Language:

english

File:

PDF, 971 KB

english, 2013

41

Novel “soft” biodegradable nanoparticles prepared from aliphatic based monomers as a potential drug delivery system

Jäger, Alessandro, Gromadzki, Daniel, Jäger, Eliézer, Giacomelli, Fernando Carlos, Kozlowska, Agnieszka, Kobera, Libor, Brus, Jiří, Říhová, Blanka, El Fray, Miroslawa, Ulbrich, Karel, Štĕpánek, Petr

Journal:

Year:

2012

Language:

english

File:

PDF, 916 KB

english, 2012

42

Polymeric carriers of drugs for site-specific therapy

Ulbrich, Karel, Pechar, Michal, Strohalm, Jiři, Šubr, Vladimír, říhová, Blanka

Journal:

Macromolecular Symposia

Year:

1997

Language:

english

File:

PDF, 334 KB

english, 1997

43

Synergistic effect of EMF–BEMER-type pulsed weak electromagnetic field and HPMA-bound doxorubicin on mouse EL4 T-cell lymphoma

Říhová, Blanka, Etrych, Tomáš, Šírová, Milada, Tomala, Jakub, Ulbrich, Karel, Kovář, Marek

Journal:

Journal of Drug Targeting

Year:

2011

Language:

english

File:

PDF, 948 KB

english, 2011

44

Ellipticine-Aimed Polymer-Conjugated Auger Electron Emitter: Multistage Organelle Targeting Approach

Sedlacek, Ondrej, Hruby, Martin, Studenovsky, Martin, Kucka, Jan, Vetvicka, David, Kovar, Lubomir, Rihova, Blanka, Ulbrich, Karel

Journal:

Bioconjugate Chemistry

Year:

2011

Language:

english

File:

PDF, 3.07 MB

english, 2011

45

Biological Evaluation of Polymeric Micelles with Covalently Bound Doxorubicin

Vetvicka, David, Hruby, Martin, Hovorka, Ondrej, Etrych, Tomas, Vetrik, Miroslav, Kovar, Lubomir, Kovar, Marek, Ulbrich, Karel, Rihova, Blanka

Journal:

Bioconjugate Chemistry

Year:

2009

Language:

english

File:

PDF, 2.84 MB

english, 2009

46

HPMA Copolymer Conjugates of DOX and Mitomycin C for Combination Therapy: Physicochemical Characterization, Cytotoxic Effects, Combination Index Analysis, and Anti-Tumor Efficacy

Kostková, Hana, Etrych, Tomáš, Říhová, Blanka, Kostka, Libor, Starovoytová, Larisa, Kovář, Marek, Ulbrich, Karel

Journal:

Macromolecular Bioscience

Year:

2013

Language:

english

File:

PDF, 611 KB

english, 2013

47

The Same Drug but a Different Mechanism of Action: Comparison of Free Doxorubicin with Two Different N -(2-Hydroxypropyl)methacrylamide Copolymer-Bound Doxorubicin Conjugates in EL-4 Cancer Cell Line

Kovář, Lubomír, Strohalm, Jiří, Chytil, Petr, Mrkvan, Tomáš, Kovář, Marek, Hovorka, Ondřej, Ulbrich, Karel, Říhová, Blanka

Journal:

Bioconjugate Chemistry

Year:

2007

Language:

english

File:

PDF, 478 KB

english, 2007

48

Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: Impact of the carrier structure onto synergistic action in the treatment of solid tumours

Etrych, Tomáš, Šubr, Vladimír, Laga, Richard, Říhová, Blanka, Ulbrich, Karel

Journal:

European Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 814 KB

english, 2014

49

Immunocompatibility evaluation of hydrogel-coated polyimide implants for applications in regenerative medicine

Sirova, Milada, Vlierberghe, Sandra Van, Matyasova, Veronika, Rossmann, Pavel, Schacht, Etienne, Dubruel, Peter, Rihova, Blanka

Journal:

Journal of Biomedical Materials Research Part A

Year:

2014

Language:

english

File:

PDF, 481 KB

english, 2014

50

Star Structure of Antibody-Targeted HPMA Copolymer-Bound Doxorubicin: A Novel Type of Polymeric Conjugate for Targeted Drug Delivery with Potent Antitumor Effect

Kovář, Marek, Strohalm, Jiří, Etrych, Tomáš, Ulbrich, Karel, Říhová, Blanka

Journal:

Bioconjugate Chemistry

Year:

2002

Language:

english

File:

PDF, 167 KB

english, 2002